Showing posts with label mesothelioma. Show all posts
Showing posts with label mesothelioma. Show all posts

Mesothelioma Symptoms

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mesothelioma cancer

MesotheliomaNotice: This website is intended to provide general information about the form of cancer known as "mesothelioma", as well as some of its known causes. This website does not claim to be complete in its discussion of the diagnosis, treatment and causes of mesothelioma. Since mesothelioma has been linked to, among other things, work related exposure to asbestos, issues of legal liability may be present in certain circumstances. The content of this web site has not been prepared or endorsed by any physicians or other licensed medical professionals. Nothing on this site should be taken as medical or legal advice. The purpose of this site is simply to provide patients and their families with useful information and access to other resources, which may be helpful. Patients are encouraged to consult with their physician for medical advice and with an attorney for legal advice. If you think that you have any of the symptoms related to mesothelioma you should contact a doctor immediately. If you have been diagnosed with Mesothelioma, or believe that you were exposed to asbestos while on the job, please click here to contact an attorney. This is a free service sponsored by the Law Offices of Patrick K.B. Tracy and there is no charge or obligation for a free case review. A lawyer will review your case at no charge. If you have further questions regarding mesothelioma, please feel free to brows our site and Mesothelioma resources.

What is Malignant Mesothelioma?The National Cancer Institute defines malignant mesothelioma as "as a rare form of cancer in which cancer cells are found in the sac lining the chest, the lining of the abdominal cavity or the lining around the heart." The medical names for these areas are the pleura, the peritoneum and the pericardium respectively and the lining around these organs is called the "mesothelium".

Malignant Peural mesothelioma therefore, is cancer which is found in the lining of the chest. Malignant Pleural mesothelioma. If Mesothelioma is found in the abdominal cavity it is known as peritoneum mesothelioma. Mesothelioma which is found in the lining of the heart is known as pericardium mesothelioma.

When mesothelioma cancer spreads, the cells of the mesothelium become abnormal. These malignant cells begin to divide and spread without order and can begin to affect organs and tissues in the immediate area. This often leads to complications in the surrounding organs.

MesotheliumThe membrane that surrounds and protects most of the body's internal organs is known as the mesothelium. It is made up of two separate layers of cells. The first is that closest to the organ itself. The second layer is what actually forms the sac around the organ. This membrane is responsible for producing a special lubricating fluid. It is this fluid that allows the organ to move around in the body un-hurt. As noted, the mesothelium has different names depending on which organ it surrounds. The peritoneum is found in the abdominal cavity and the pleura surrounds the lungs and chest cavity.

The National Cancer Institute states that "[m]ost people who develop mesothelioma have worked on jobs where they inhaled asbestos particles."

>> Mesothelioma Risk FactorsAsbestos exposure also is the cause of asbestosis, a chronic lung ailment that can produce shortness of breath, coughing, and permanent lung damage.

If you have been diagnosed with Mesothelioma as a result of Asbestos exposure, YOU MAY BE ENTITLED TO MONETARY COMPENSATION!

Small Cell Lung Cancer and Malignant Mesothelioma

Abstract

Overview

Introduction

SCLC accounts for one-fifth of all lung tumor types. More than 80,000 new cases are expected to be diagnosed in 2007 in the seven major markets, although it is set to decrease due to changing smoking habits. Mesothelioma is rarer, although incidence is expected to increase in the coming years in Europe and Japan given the heavy use of asbestos in the 1970s and long latency period of the disease.

Scope of this report

  • Overview of small cell lung cancer (SCLC) and mesothelioma, including epidemiology, staging, prognosis and unmet needs
  • Review of current treatment modalities and physician opinion of existing and future treatment strategies
  • Evaluation of key drugs currently used in the treatment of SCLC and mesothelioma
  • Assessment of late-phase drugs in development for SCLC and mesothelioma including key opinion leaders' view on their potential

Research and analysis highlights

Despite decreasing incidence, unmet needs in SCLC remain high due to poor prognosis and lack of effective treatment. R&D interest in the disease is low; however, this represents an opportunity for developing companies in the SCLC market.

Alimta is approved for other lung cancer indications including NSCLC and mesothelioma. It is in a Phase III trial in SCLC and Datamonitor believes that, although unlikely to show significant efficacy advantage over current standard, Alimta may potentially demonstrate toxicity advantages, in which case, it may usurp etoposide as standard therapy.

Incidence of malignant mesothelioma may have peaked in the US but is set to increase over the next two decades in Europe and Japan due to the later uptake of asbestos in these markets. Nevertheless, overall incidence of mesothelioma remains low; as is the R&D interest in the disease.

Key reasons to read this report

  • Evaluate opportunities and risks in the SCLC and mesothelioma markets by analyzing the clinical and commercial attractiveness of key drugs
  • Assess key success factors that drive the SCLC and mesothelioma markets to estimate the potential of existing and pipeline drugs for the diseases
  • Understand current and future competitive dynamics of SCLC and mesothelioma to determine the future size and scope of the markets

Table of Contents

  • ABOUT HEALTHCARE
    • About the Oncology pharmaceutical analysis team
      • Nish Saini - Lead Analyst, Oncology
  • CHAPTER 1 EXECUTIVE SUMMARY
    • Scope of analysis
  • CHAPTER 2 SCLC OVERVIEW
    • Introduction
    • Subtypes
    • SCLC strongly associated with smoking
    • Diagnosis
    • Staging - VALG or IASLC system?
      • Nearly two-thirds are diagnosed in extensive stage
    • Prognosis
      • Poor prognosis in extensive stage
      • Slow improvement in prognosis
    • Epidemiology
      • One-fifth of lung cancer cases are SCLC
      • Decreasing incidence of SCLC
      • Incidence calculation
      • Incidence forecast calculation
  • CHAPTER 3 CURRENT SCLC TREATMENT OPTIONS
    • Introduction
    • Treatment modalities
      • Limited stage
        • Surgical care remains confined to few patients
        • Quality of surgery depends on surgeon specialty
        • Surgery plus chemotherapy
        • Chemoradiotherapy improves survival in limited stage SCLC
        • Prophylactic cranial irradiation (PCI) for distant recurrence
      • Extensive stage
        • Chemotherapy alone is the primary treatment modality
    • Chemotherapy regimens
      • CAV superseded by PE regimen
      • Addition of a third agent to PE brings mixed results
        • Ifosfamide improves survival at the expense of increased toxicity
        • Paclitaxel not recommended for SCLC
        • Taxotere confers modest efficacy
      • Alternating regimens?
      • Carboplatin as alternative to cisplatin
        • Carboplatin plus etoposide more popular than cisplatin plus etoposide in the EU
      • Irinotecan in Japan
        • Success not replicated in the West
      • Amrubicin in Japan
      • High-dose and dose-intense chemotherapy in SCLC
      • Second-line therapy
        • Hycamtin remains the only approved drug for relapsed SCLC
        • No standard therapy for refractory SCLC
        • Amrubicin is used commonly in Japan
        • Summary of Phase II trial results for second-line SCLC
  • CHAPTER 4 UNMET NEEDS IN SCLC
    • Introduction
    • Unmet needs
      • Improving prognosis of SCLC
        • Need for earlier diagnosis
        • Strong association with smoking
        • Low curative surgery rate
        • Lack of efficacious drugs
      • Less toxic drug regimens required
      • Low R&D interest
  • CHAPTER 5 SCLC PIPELINE ANALYSIS
    • Pipeline drugs for SCLC
      • Pipeline drugs by phase
        • Low number of Phase III drugs
      • Pipeline drugs by drug class
        • Two-thirds are molecular-targeted therapy
      • Pipeline drugs by phase and drug class
    • Late-phase pipeline drug profile
      • Alimta (pemetrexed) - Eli Lillly
        • Profile
        • Trial results
        • Toxicity may be the key for Alimta in SCLC
        • Potential US patent extension for Alimta
      • Thalomid (thalidomide) - Celgene/Pharmion
        • Trial results
        • Limited potential in SCLC
      • Other key pipeline drugs in Phase II development
      • Picoplatin - Poniard Pharmaceuticals
      • Avastin (bevacizumab) - Genentech/Roche
      • Nexavar (sorafenib) - Bayer Schering/Onyx
      • Iressa (gefitinib) - AstraZeneca
      • Recentin (AZD2171) - AstraZeneca
  • CHAPTER 6 MALIGNANT MESOTHELIOMA
    • Disease overview
      • Types of mesothelioma
      • Causes
      • Staging
        • Stage distribution
      • Prognosis
      • Epidemiology
    • Current treatment options
      • Surgery
      • Radiotherapy
      • Chemotherapy
        • Alimta
        • Gemzar
    • Unmet needs in malignant mesothelioma
    • Pipeline analysis
      • Pipeline drug by phase
      • Pipeline drug by drug class
      • Late-phase pipeline drug profile
        • Zolinza (vorinostat) - Merck & Co
        • Onconase (ranpirnase) - Alfacell
  • APPENDIX
    • Contributing experts
    • UN Population Data
    • Bibliography
    • List of tables
    • List of figures
      • About the Oncology analysis team
    • Disclaimer
    • List of Tables
      • Table 1: Incidence of SCLC in the seven major markets, 2002
      • Table 2: Estimated incidence rates for SCLC, 2002-2016
      • Table 3: Forecast SCLC incidence, 2007-2016
      • Table 4: Five-year survival rates following resection by stage
      • Table 5: Results of major 1980s and 1990s trials of neoadjuvant chemotherapy in SCLC, 1984-1994
      • Table 6: Results of Phase II trial by Tsuchiya et al. (2005)
      • Table 7: Results of major trials of adjuvant chemotherapy in SCLC, 1978-2000
      • Table 8: Indirect comparison of amrubicin versus topotecan in second-line SCLC, 1997-2006
      • Table 9: Summary of recent Phase II trial results for second-line treatment of SCLC, 2003-06
      • Table 10: Pipeline drugs for SCLC, 2007
      • Table 11: Ongoing late-phase clinical trials for SCLC, 2007
      • Table 12: Summary results of Phase II trial by Socinski et al. (2006)
      • Table 13: Summary results of Phase III trial by Breton et al. (2006)
      • Table 14: Summary results of Phase II trial by Cooney et al. (2005)
      • Table 15: Ongoing Phase II trials of Avastin in SCLC, 2007
      • Table 16: Various staging systems used for mesothelioma
      • Table 17: Epidemiologic features of malignant mesothelioma, 2005
      • Table 18: Summary results of Phase III trial by Vogelzang et al. (2003)
      • Table 19: Pipeline drugs for malignant mesothelioma, 2007
      • Table 20: Ongoing late-phase clinical trials for mesothelioma, 2007
      • Table 21: Summary results of Phase II trial by Mikulski et al. (2002)
      • Table 22: Interim analysis of Phase IIIb trial for Onconase in mesothelioma, 2006
      • Table 23: UN Population Data, 2002-2016
    • List of Figures
      • Figure 1: Anatomy of the respiratory system
      • Figure 2: Stage distribution at diagnosis
      • Figure 3: Two-year survival rate and median survival by stage
      • Figure 4: Five-year survival rates of NSCLC and SCLC in the US, 1975-2002
      • Figure 5: Two- and five-year survival rates for SCLC in the US, 1973-2002
      • Figure 6: Proportion of SCLC versus NSCLC in the US and EU, 2006
      • Figure 7: Incidence rate of SCLC in the US,1975-2003
      • Figure 8: Incidence of SCLC in the seven major markets, 2002
      • Figure 9: Forecast SCLC incidence, 2007, 2010, 2013, 2016
      • Figure 10: Use of various chemotherapy regimens in the EU for SCLC in first line, 2006
      • Figure 11: Use of various chemotherapy regimens in Japan for SCLC in first line, 2005
      • Figure 12: Sales volume of cigarettes in China, 1981-1995
      • Figure 13: Pipeline drugs for SCLC by phase, 2007
      • Figure 14: Pipeline drugs for SCLC by drug class, 2007
      • Figure 15: Pipeline drugs by phase and drug class, 2007
      • Figure 16: Percentage use of Alimta by indication in the five major EU markets, 2006
      • Figure 17: Summary results of Phase II trial by Socinski et al. (2006)
      • Figure 18: Correlation between mesothelioma incidence and asbestos use, 1995-2000
      • Figure 19: Stage distribution at diagnosis in the US, 1996-2002
      • Figure 20: Five-year survival rates for mesothelioma in the US, 1975-1998
      • Figure 21: Incidence rate of malignant mesothelioma in the US, Europe and Japan, 2005
      • Figure 22: Unmet needs in malignant mesothelioma, 2007
      • Figure 23: Pipeline drugs for mesothelioma by phase, 2006
      • Figure 24: Pipeline drugs for mesothelioma by drug class, 2006

Datamonitor
Global Information, Inc.
US $ 3800
 

Who needs to be examined for Asbestosis or Mesothelioma?

Individuals who have been exposed to asbestos (or suspect they have been exposed) dust on the job or at home via a family contact should inform their physician of their exposure history and any symptoms. Asbestos fibers can be measured in urine、feces、mucus、or material rinsed out of the lungs. A thorough physical examination、including a chest x-ray and lung function tests、may be recommended.

It is important to note that chest x-rays cannot detect asbestos fibers in the lungs、but they can help identify any lung changes resulting from asbestos exposure. Interpretation of the chest x-ray may require the help of a specialist who is experienced in reading x-rays for asbestos-related diseases. Other tests also may be necessary.

As noted earlier、the symptoms of asbestos-related diseases may not become apparent for many decades after exposure. If any of the following symptoms develop、a physical examination should be scheduled without delay:

Shortness of breath;

A cough or a change in cough pattern;

Blood in the sputum (fluid) coughed up from the lungs;

Pain in the chest or abdomen;

Difficulty in swallowing or prolonged hoarseness; and/or

Significant weight loss.

Mesothelioma Symptoms

Symptoms of mesothelioma may not occur for 30 to 50 years after an individual is exposed to asbestos. Unfortunately、the early symptoms of mesothelioma are often non-specific and can sometimes be confused with other illnesses such as pneumonia. Part of the reason that Mesothelioma is often misdiagnosed is that many of the symptoms are similar to pneumonia、including shortness of breath、persistent cough and chest pain. These similarities can sometimes lead to a delay in a mesothelioma diagnosis. Making matters more difficult is the fact that some patients show no symptoms of their mesothelioma.

When symptoms of mesothelioma do appear、they often manifest themselves as shortness of breath and chest pains. The exact symptoms will often depend on which area the mesothelioma is affecting. For instance、some symptoms of peritoneal mesothelioma include weight loss、abdominal pain、bowel obstruction、anemia and fever.

ONLY A DOCTOR CAN PROPERLY DISGNOSE MESOTHELIOMA

IF YOU THINK YOU HAVE ANY OF THESE SYMPTOMS、YOU SHOULD CONTACT A DOCTOR IMMEDIATELY.

Help with mesothelioma

Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or have been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products. There is no association between mesothelioma and smoking.

Why we need Mesothelioma Lawyers.

The one-time friend turned killer that was once such an indispensible, yet unnoticed, part of our daily lives for so many centuries, is now a feared enemy. It is Asbestos (from the Greek for 'inextinguishable') and is the reason behind thousands of global compensation claims, through mesothelioma lawyers, against employers, manufacturers and processors of asbestos-related products. Anyone suspecting they may be suffering as a result of exposure to asbestos, would be well advised to seek the services of specialist mesothelioma lawyers, whose experience with industrial diseases can be of great help in reducing the anxiety and uncertainty people may face taking confirmed cases through the sometimes long process of of legal compensation.

Many asbestos workers, and those unwitingly exposed to asbestos, have been given a mesothelioma diagnosis for which there is no cure, maybe just a little temporary relief, until the inevitable distressing death a few months or a year or two after the first symptoms of are noticed. This is why it is important for suspected sufferers to contact mesothelioma lawyers as soon they realise there may have been exposure to asbestos fibres or dust, over no matter how short a period.